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Inspired by Nature

Through millions of years of evolution, the blue crayfish developed a remarkable survival mechanism that enables it to collect and store calcium from its exoskeleton before shedding, store the calcium temporarily and then re-absorb it to build a new exoskeleton in less than 72 hours.

The key to this ability is a unique form of calcium called Amorphous Calcium Carbonate (ACC).* While reabsorbing calcium from its exterior shell before shedding, the crayfish stores the ACC in two special organs called Gastroliths, which are located at the top of its stomach. When the calcium is needed, the Gastroliths drop into the stomach acid and quickly dissolve. The calcium ions from the ACC quickly mobilize across the crayfish’s intestinal barrier to form a new exoskeleton.

Along with its synthetic ACC pipeline, Amorphical continues to explore the therapeutic advantages of natural Gastrolith ACC in order to develop additional innovative medical treatments for calcium-related diseases.

* HEALTH (2013)
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** PNAS (2008)
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*** JBMR (2010)
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**** JBMR (2014)
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